Anti-Mage is a melee agility carry for the radiant faction in Dota 2. He is known primarily for his high mobility thanks to his blink ability and as being, as his name implies, the bane of magic casters.

Solaire of Astora is the leader of the Warrior of Sunlight and a recurring character in Dark Souls. He is first met on the landing of the Undead Parish, where the player arrives after beating the Taurus Demon, and hands over the White Sign Soapstone, which allows players to be summoned to help another. When in human form, the player can call on Solaire's assistance for many of the game bosses, including Gwyn, Lord of Cinder.

Doomsday was originally a young Kryptonian long before humanoids controlled the planet. Experimented on by the scientist Bertron, he was adapted to suit the harsh envorinment on the planet. Eventually Doomsday managed to escape from the planet and began his murderous rampage.

Kilian Samuels is the main protagonist in Prey 2.

Oswald of Carim is a pardoner of sins and allows players to safely abandon covenants in Dark Souls. He is first encountered after ringing the Bell of Awakening in Undead Parish at the bottom of the bell tower. Selling Karmic Justice and offering the Book of the Guilty, Oswald has knowledge of all sins that transpire in Lordran and offers sinners the chance to absolve their sins...at a "small" cost.

Reese is a character in the Animal Crossing: New Leaf.

Voodoo Pizzaman is a recurring character in the Tropico series of games. He is always seen with his top hat, as well as a Tropican cigar.

Quelana of Izalith is the mother of pyromancy and a magic trainer of pyromancy in Dark Souls. She is found in the poisonous swamp of Blighttown, directly across from the entrance to Quelaag's Domain after ringing both Bells of Awakening.

Lautrec of Carim is a knight and follower of the goddess Fina in Dark Souls. He is found imprisoned on the top floor of the Undead Parish church, past the Zombies and Channeler, and requires the Mystery Key to be freed. Once freed, he will appear in Firelink Shrine and can be called to assist the player in fighting the Bell Gargoyles and Gaping Dragon.

Davy Jones is a cursed captain of the Flying Dutchman and a main antagonist from the Pirates of the Caribbean films Dead Man's Chest and At World's End. Originally a normal man, Jones fell in love with the goddess Calypso and was tasked with ferrying the souls of those lost at sea. Betrayed by Calypso, Jones cut out his heart and place it in Dead Man's Chest before gathering the Pirate Brethren and imprisoning Calypso away in human bonds. Cursed for abandoning his job as the ferryman, Jones and his crew were turned into sea monsters and ruled the seas with the Kraken at his side.

Irisa is a scrappy young Irathient woman whose life revolves around her relationship with Joshua Nolan, the man who rescued her and raised her like a daughter.

Louis Mills was a deckhand aboard the Providence, which sailed from England to Boston, and a member of the Assassin Order in Assassin's Creed III. Like his father, Mills was in love with the sea and set sail for the first time at the age of 10 with his father.

Uni is a recurring character in the Hyperdimension Neptunia franchise and the little sister of Noire. As a CPU Candidate, she is the personification of the Sony PlayStation Portable.

Nepgear is the main protagonist of Hyperdimension Neptunia mk2 and a recurring character in the franchise of the same name. As a CPU Candidate, she is the personification of the Sega Game Gear.

Pontius is a playable character in the Trine series.