Elizabeth, despite her youthful appearance, is actually 21 years old. She is one of the two main characters in BioShock Infinite, and the main non-player character.

Eddy Raja is an Indonesian villain in Uncharted: Drake's Fortune, and an old friend of Nathan Drake. In the video comic series Eye of Indra, they work together on a heist, but they become enemies when Raja sides with Gabriel Roman in the events of Drake's Fortune.

Escha Malier is one of two main protagonists in Atelier Escha & Logy: Alchemist of Dusk Sky.

Eddie Pulaski is a character from Grand Theft Auto: San Andreas. He is Frank Tenpenny's partner in C.R.A.S.H., a unit designed to fight against the gangs in Los Santos. However, they are corrupt and use their power to do a lot of dirty work. He ends up getting killed by CJ in Bone County, with his last request being to sleep with CJ's sister, Kendl Johnson.

Elizabeth Anne Greene (also known as Mother), is a character in the game Prototype. She is the result of an experiment.

Esther is a character from Ni no Kuni: Wrath of the White Witch.

Elastigirl is the matriarch of the Parr family and one of the main characters of the Pixar film, The Incredibles. She is married to Bob Parr (Mr. Incredible) and has three children with him: Violet, Dash, and Jack-Jack. Her superpower is the ability to stretch any part of her body up to 100 feet, and as thin as 1 millimeter. She can also form her body into a variety of shapes, such as a boat or parachute.

Erk is a secondary character in Fire Emblem, and makes minor appearences in the DLC and SpotPass content of Fire Emblem: Awakening.