Quina is a NPC in Dragon's Dogma.

Quelana of Izalith is the mother of pyromancy and a magic trainer of pyromancy in Dark Souls. She is found in the poisonous swamp of Blighttown, directly across from the entrance to Quelaag's Domain after ringing both Bells of Awakening.

Q-Bee is a character from the Darkstalkers series of games, making her first appearance in Darkstalkers 3.

Quote (aka Mr. Traveler in Cave Story 3D) is the silent protagonist of Cave Story and Cave Story 3D. He isalmost never mentioned by name, except by his companion Curly Brace, and is described as an "armed recon robot" built to resemble a human boy.