Sieglinde of Catarina is the daughter of Siegmeyer of Catarina and a non-playable character in Dark Souls. Traveling Lordran in search of her father, she can be found in a Golden Crystal Golem in the area between The Duke's Archives and the Crystal Caves.

Saharah is a character from the Animal Crossing series of games.

Siegmeyer of Catarina is the father of Sieglinde of Catarina and a recurring character in Dark Souls. He is first seen outside the gate of Sen's Fortress and is encountered many more times needing help from the player.

Saltonstall is an elderly politician in Columbia, and is a member of the Founders political faction. Judging by the posters found around Columbia, he is running for councilman of Ward 6.

Sly Cooper is the main character of the Sly Cooper series of games.

Saren Arterius is a rogue Turian Spectre and one of the principal antagonists of the original Mass Effect. It is revealed that he is working with Sovereign and the other Reapers to pave the way for their invasion, enlisting the Geth to help him in his fight.

Skull Kid originally appeared in Ocarina of Time on the N64, and later appeared in Twilight Princess on the Wii and Gamecube as an enemy in the Lost Woods. He can also be found hidden in places throughout the Lost Woods in Twilight Princess.

Solaire of Astora is the leader of the Warrior of Sunlight and a recurring character in Dark Souls. He is first met on the landing of the Undead Parish, where the player arrives after beating the Taurus Demon, and hands over the White Sign Soapstone, which allows players to be summoned to help another. When in human form, the player can call on Solaire's assistance for many of the game bosses, including Gwyn, Lord of Cinder.