Ukyo is a famous photographer and a recurring character in the Amnesia series. Suffering from multiple personalities, Ukyo can be kind and caring when OmoteUkyo is in control or dangerous and menacing when UraUkyo is in control.

Ugga Crodd is an open-minded cavewoman and Grug's wife in The Croods: Prehistoric Party! Like Grug, she is worried about keeping her family safe, but doesn't necessarily believe that not leaving the cave is the answer. So when an earthquake forces the Croods to abandon their home and leave behind everything they know behind, she starts to worry even more.

Utakata (ウタカタ, Utakata) was a missing-nin from Kirigakure and the jinchūriki of Saiken, the Six-Tails, which has been captured and sealed by Akatsuki, causing his death when the beast was extracted. However, upon his reincarnation, Saiken was resealed within Utakata.

Usagi is Pleinair's doll and co-host on SatilTV in Disgaea 2: Cused Memories. He also appears in Disgaea DS in Pleinair's unique special, Usagi Drop.

Underling, real name Linda, is a villian in Hyperdimension Neptunia Mk-2, who constantly challenges the CPU Candidates as they try and gather the resources to save the Goddesses from the Gamindustri Graveyard.

Uni is a recurring character in the Hyperdimension Neptunia franchise and the little sister of Noire. As a CPU Candidate, she is the personification of the Sony PlayStation Portable.

Ulala is a rhythmic space reporter who loves to dance and stars in the Space Channel 5 series. She has appeared in all SEGA Superstars/Allstars games.