Zetsu (ゼツ, Zetsu) is a member of Akatsuki and one of Obito Uchiha's most loyal subordinates. The black half is known as Black Zetsu (黒ゼツ, Kuro-Zetsu), while the white half was known as White Zetsu (白ゼツ, Shiro-Zetsu).

Zhang Jiao (Chou Kaku in Japanese) is a character from the Three Kingdoms era of Chinese history that has been featured in a number of KOEI series, mainly in the Dynasty Warriors, Warriors Orochi and Romance of the Three Kingdoms series.

Zachary Hale Comstock is the lead of The Founders in the video game BioShock Infinite.

Zigo d'Acosta is one of the playable multiplayer characters in BioShock 2.

Zeldalia is a character in Atelier Iris: Eternal Mana and one of the most powerful alchemists in the land. Although she looks young, she is actually much older and suffers from a bad hip. She lives inside Poto Forest with Norn, who she found as a wild cat and transformed her into a girl.

Zoya is a playable character from the Trine series.

Zero is the last creation built by Dr. Wily, and is a NPC and playable character in the Mega Man X series. He eventually gets his own game series in Mega Man Zero, as well as makes an appearance in Mega Man ZX.