Alternate Ending
Successfully complete the game on the normal difficulty setting with a B or higher rank to unlock hard mode
Defeating Nitro
When you go into battle with Nitro you will find her very annoying Use the following trick to damage her When you first start go near her and use the blue serum on her It will make the things floating near her to go up When the attack is charged release and each floating thing will do over 700 damage to her The serum can also be used as a shield from her attacks
Defeating Spider
After defeating Dorothy in your first fight you will go to the start of the level and make your way past the rooms You will fight a boss named Spider Try to move away from the dangling spiders His weakness is Fire red serum When a spider gets on you press R1 shield to get them off You cannot attack him with DFelon blue serum When he comes down from his web use Fire or Nalcon on him After you defeat him you obtain a Skip allows you to improve a serum ability Use your Skip on the Nalcon as it will be needed later Then open the gate and cross the bridge to Dorothy
Dorothy
When you start your first fight with Dorothy attack with the Nalcon green serum Continue attacking her and try not to stand on the lighted spaces and dodge the eyeballs
Extra skip
In the Enriched Uranium Refinery in the room where you format the security card to quotSaturnusquot defeat all the red and gray robots after you talk to Ash over the security screen
Get Hard Mode
Finish the game on Hard difficulty with a S rank
or better
Hard mode
Successfully complete the game on the normal or hard difficulty setting