Azrael is the Archangel of Death and a conspirator of the Apocalypse, along with Abaddon and Ulthane, in Darksiders. After Ulthane forged the Armageddon Blade, Azrael found and destroyed six of the Seven Seals that would begin the war. Unfortunately, Hell's army was prepared and Straga defeated Abaddon.
After Abaddon's return, Azrael unwittingly lead him to the Tree of Knowledge, desperate to believe in his friend. After receiving his gift, Abbadon returned to Earth as the Destroyer and sent Straga to imprison Azrael within The Black Throne, and seizing control over the Well of Souls. When War reaches The Black Throne, Azrael aids him in reaching Eden to take on the Destroyer.