Megaera is one of the three Furies that Kratos will fight in God of War: Ascension, which were created from the madness and a war that was raged between the Primordials. They were tasked with punishing the treacherous and wicked. Her sisters are Tisiphone and Alecto.
Megaera appears in the beginning of the game, waking up a chained Kratos in the Hecatonchires. He was imprisoned there because of his betrayal towards Zeus. While attacking him, one of her slashes frees him from the restraint around his neck, allowing him to stand up. This leads to a battle between the two, which eventually leads to one of the Hecatonchires' arms, where she summons some beastly monster and flees.