Dr. Brigid Tenenbaum is a genetic scientist who helped develop ADAM in the BioShock series and the creator of the Little Sisters. Raised near the city of Minsk in Belarus, at the age of sixteen years old she was taken from Minsk to become a prisoner at the Nazi concentration camp at Auschwitz. Watching the doctors perform experiments on prisoners, she gained a love of science and was eventually put to work assisting them.

After her arrival in Rapture, Tenenbaum discovered a smuggler whose crippled hands had been restored to normal after being bitten by a sea slug. Researching the slug, she found that the slug produced a substance dubbed ADAM, which it could heal damaged cells. Using gene splicing, ADAM granted its users superpowers, called Plasmids. Initially turned away by other researchers, Frank Fontaine funded the research to mass-produce ADAM in the bodies of hosts (Little Sisters).

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