Japan's Self-Defense Force requests Ryu's assistance with a terrorist incident in London by a cult calling themselves the "Lords of Alchemy". Specifically calling out for Ryu's appearance, he complies and heads out with JSDF member, Mizuki McLoud.
During a rescue operation to save the hostage British Prime Minister and his family. Ryu encounters the cult's leader, "Regent of the Mask", a masked swordsman with devastatingly fast sword skills. After a quick battle, The Regent curses Ryu's arm with the "Grip of Murder", kills the Prime Minister, and flees. Following the loss, the Lords of Alchemy broadcast a message stating the world's total annihilation if every nation does not surrender within seven days.