There are 46 The Amazing Spider-Man achievements worth 1,000 GS.
| Gladiator | 15 |
| Completed all Oscorp Secret Research Labs | |
| A Dash of Spider | 15 |
| Completed all XTreme Race challenges | |
| The Camera Loves You | 15 |
| Completed all XTreme Video challenges | |
| Friendly Neighbor | 15 |
| Saved a hostage caught in a petty crime | |
| Call Interrupted | 15 |
| Destroyed a Seeker before it could call a Hunter | |
| Negotiator | 15 |
| Resolved all police deadlocks | |
| Car Hopper | 15 |
| Cleared all car chases | |
| Peace of Mind | 15 |
| Returned all escapees to the police | |
| Sanitized | 15 |
| Rescued all infected civilians | |
| Sky Captain | 15 |
| Chained 10 Web-Rushes in the city | |
| Amazing Spider-Man | 20 |
| Unlocked all concept art | |
| Ultimate Spider-Man | 20 |
| Acquired all upgrades | |
| Heavyweight Champion | 30 |
| Defeated 1000 enemies | |
| Middleweight Champion | 20 |
| Defeated 500 enemies | |
| Lightweight Champion | 15 |
| Defeated 100 enemies | |
| The Sky Is the Limit | 20 |
| Defeated the S-01 without touching the ground | |
| Clean Victory | 20 |
| Defeated a Hunter without using your Web-Shooters | |
| All Tied Up | 15 |
| Defeated 100 enemies by performing Stealth Takedowns | |
| Stick to the Plan | 15 |
| Defeated 50 enemies by performing Stealth Takedowns | |
| Keep It Together | 15 |
| Immobilized 6 enemies simultaneously with web | |
| Haymaker | 10 |
| Performed a Web-Rush punch | |
| FYI I'm Spider-Man | 10 |
| Performed 25 Signature Moves | |
| I'm on a Roll! | 15 |
| Achieved a combo streak of 42 | |
| Journalist | 15 |
| Collected all audio evidence | |
| Corporate | 15 |
| Collected all Oscorp Manuals | |
| Tech Savvy | 15 |
| Collected all hidden Tech Pieces | |
| Librarian | 15 |
| Collected all magazines | |
| On the Fly | 25 |
| Collected all 700 Spider-Man Comic Pages | |
| Spider-Man | 100 |
| Completed the game on super hero difficulty | |
| Vigilante | 50 |
| Completed the game on hero difficulty | |
| Peter Parker | 25 |
| Completed the game on human difficulty | |
| Secret Achievements | |
| Pest Control | 20 |
| Defeated Scorpion in the city | |
| Speed Bump Ahead | 20 |
| Defeated Rhino in the city | |
| Welcome Back, Friend | 30 |
| Defeated Lizard | |
| Deeply Sorry | 20 |
| Defeated Nattie | |
| Smell You Later | 20 |
| Defeated Vermin | |
| Jinxed | 20 |
| Defeated Felicia | |
| Tail? You Lose | 20 |
| Defeated Scorpion in quarantine | |
| Down for the Count | 20 |
| Defeated Rhino in the sewers | |
| Switched Off | 25 |
| Rescued Alistaire Smythe | |
| Apparent Defeat | 20 |
| Defeated Iguana | |
| Tomorrow Is Saved | 30 |
| Defeated the S-03 | |
| Big Apple, Big Worm | 30 |
| Defeated the S-02 | |
| Siege Averted | 30 |
| Defeated the S-01 | |
| Beating the Odds | 30 |
| Cleared the second fight against the Hunter robots | |
| Who's the Prey? | 30 |
| Cleared the first fight against the Hunter robots | |
