The following characters are available without completing the campaign:
- Jill Valentine
- Chris Redfield
- Parker Luciani
To unlock the other characters you will need to complete the following:
| Keith Lumley | Clear campaign Episodes 4-6. |
| Jessica Sherawat | Clear all Raid Mode stages on Chasm difficulty. |
| Quint Cetcham | |
| Raymond Vester | Clear every stage on Chasm difficulty |
| Clive R. O'Brian | Clear every stage on Abyss difficulty |
| Morgan Lansdale | Find the real exit on stage 21 |
| Jack Norman | Obtain all rare weapons |
| Rachael Foley | Finish any stage with a Trinity bonus |
| Hunk | Finish every stage on Abyss difficulty with an S rank |
Costumes
Aside from the starting costumes the player can unlock alsternate costumes by completing parameters in Campaign Mode or Raid Mode. The following shows the costumes with the unlock conditions:
| Jill Valentine | |||
|---|---|---|---|
 |  |  | |
| Default | BSAA | Pirate | |
| - | Obtain a super rare weapon. | Clear The Ghost Ship bonus Stage. | |
| Chris Redfield | |||
 |  |  | |
| Default | BSAA | Sailor | |
| - | Reach level 30. | Inflict 100,000 points of damage to an enemy in one hit. | |
| Parker Luciani | |||
 |  |  | |
| Default | BSAA | FBC | |
| - | Earn 10 bonuses. | Defeat 10,000 enemies. | |
| Keith Lumley | |||
 |  |  | |
| Arctic | Office | Ninja | |
| Clear campaign Episodes 4-6. | Clear all stages on Chasm difficulty with an S Rank. | Reach level 50. | |
| Jessica Sherawat | |||
 |  |  | |
| Arctic | Scuba | FBC | |
| Clear all Raid Mode stages on Chasm difficulty. | Clear all Raid Mode stages on Trench difficulty. | Reach level 40. | |
| Quint Cetcham | |||
 |  | ||
| Arctic | Office | ||
| Reach level 5. | Obtain all super rare weapons. | ||
| Raymond Vester | Clive R. O'Brian | Morgan Lansdale | |
 |  |  | |
| FBC | BSAA | Executive Suit | |
| Reach level 10. | Reach level 20. | Clear all stages on Trench difficulty with an S Rank. | |
| Jack Norman | Rachael Foley | ||
 |  |  | |
| Velto | FBC | Ooze | |
| Obtain all rare weapons | Earn a Trinity Bonus. | Pre-orders of the Unveiled Edition | |
| HUNK | |||
 |  | ||
| Unbrella | Lady | ||
| Clear all stages on Abyss difficulty with an S Rank. | - | ||
