When I heard Bernie over the radio, I didn't think her voice fit the image I had of her but after seeing her, I think it works pretty alright. Choose to ride out; it's the more fun option. It's not really all the complicated. The first part is just an on rails section for about 15 seconds, and then you jump off, fight on foot for a quick spell and then head back to the Fort. You'll get attacked by lambent on the way back so fight them off. Eventually you will meet the Lambent Zerker. You can't do anything about it now, just try to make your way to the base and when they say run for the gate, and do so. If you saw the E3 2010 demo, this is pretty much it and it really hasn't changed.
Once inside, the fight continues. The Lambent Zerker is not completely immune to regular weapons which has a plus and a minus. You don't need the Hammer of dawn to kill it but the only part that you can actually cause damage to is her heart. She only exposes her heart when she's charging so you aren't just leading her someplace and then killing her any more. This is more about playing chicken. There are collectables here that you need to collect during the battle. The area is round and in the middle is a tower. If you assume the area is a clock with the main gate being 12 then at about two are some COG tags by a barrel in the corner and in the center at six (up against the middle tower) is a book on the ground. Make sure you get both.
After she's sustained enough damage, she'll start leaking immulsion which will cause burn damage if you walk over it. So then you are still playing chicken but you also can't go back past where she's been so you need to be efficient about your space usage. Continue to shoot her heart when she charges and you'll get a cutscene and she'll die.
*cutscene*