Head forward and up the stairs into the main room of Inner Persephone where you'll learn of what's ahead of you. If you look at a map, you'll see the center room you are in and the three arms of Inner Persephone. Basically you will have to go through each arm in turn. Almost there, good luck!
Go upstairs, across the middle platform and head toward the south. Go through the door and into a room where you need to hack a door switch through the window. Then go through the door you just opened and into another room. Hit the button on the other side of the bars and then when you get the chance, go through the door you just opened.
Go down the stairs and take a right into the Cafeteria. Move into the serving area and through the door on the other side. Go down the stairs and you'll come to a landing on the bottom floor with a Brute Splicer. Kill him and go through the door. Go through to the Laundry area and follow Sinclair up the stairs. Then go into the Cell Block where you'll be locked in.
In the next room is a security camera (behind the pillar), hack it then return back up the stairs and hack the health station. Then follow the walk way around and into the next room. Walk into Block A and there's a small room off to the left with a hole in it. Hack the door control in the distance, then light the oil on the ground to lure Sinclair out. He'll be in the area, you need to find him and kill him. Thankfully he's not really any harder than the other Alphas. He will be carrying a grenade launcher though so watch out. Then Walk into the room he was in to use the Power to the People station.
Make sure you are ready, you are about to make a made dash. As soon as you flip the switch, you'll have to wade your way through an army of Alphas back to the main room of Inner Persephone.
Now you have two options. You can go to the Infirmary or the Therapy wing. You have to do both and it doesn't really matter which order you do them in.
The Infirmary: Walk into the Infirmary and through the first room with the gurney. In the next room you'll see a splicer and a security camera. After you've dealt with this room, follow the arrow around some. The next splicer you see will be a Houdini but he'll be harmless. Just after you get beyond him you'll come to a room with a dead splicer in a chair and stairs to your left. Head up the stairs and into Surgery. In each of the next two rooms will be security cameras.
After that you'll be above the first big room of the infirmary (the one with the security camera). The next step is pediatrics.
In Pediatrics you'll face a couple of Alphas, some Houdini's and some leadheads. You'll need to clear the room. Call Eleanor and then head up either side and part way across the room you'll see stairs leading up to the top. From up here you should be able to handle the fight no problem. Just watch for Houdini's who might teleport up here.
After you clear the room, head over to the door of the chamber and hit the button to signal Eleanor. You don't have to wait for her, just head back the way you came out of the pediatrics area. Then jump down into that first room and out into the main room of Persephone again.
Therapy: This is actually really easy. Walk into therapy and you basically walk straight through it to the pediatrics area. Just follow the arrow and you will most likely get through therapy unaccosted. Walk through the pediatrics room and out to the end where there will be a turret to the left and a health station to the right. And most likely an Alpha right in front of you. This is probably the ideal spot to work from. You'll have Alphas, Houdinis, and a Brute or two. Once you're done with them, signal Eleanor.
Head back out the way you came. Return to the Docking Platform. Use all your Adam, spend almost all your money (keep enough to use for healing if need be) and stock everything you can. Then plant traps all over the room in a way that would keep someone (that's you) safe while they were up against the door to the shuttle. Don't use all of your mini-turrets right away since they blow up eventually and make sure you keep your bots around you. This is it. Get ready for your final fight.
The final fight will consist of just the regular enemies you're used to at this point. There will be Alphas, LOTS of Brutes, some Houdinis and leadheads. The first leg is pretty tough and you won't be able to get help from Eleanor. After a little bit, though, Eleanor will finish what she's doing and be able to help you. Then the fight gets really hectic but she really helps even the odds. It's also a nice time to watch how Big Sisters work from an outside perspective. Anyway, tear everything to pieces. Use all of your anti-personel ammo. As always, Good Luck!
After a little bit of fighting, she'll tell you to flip the switch. Run up the stairs and in the middle of the room you'll see it. Flip it and then she'll tell you that you need to break a couple of tubes. Look up and left or right. There's two of them and they'll glowing ready and easily visible from where you are. Shoot at them until the blow up and then once the room is flooded, follow the arrow until you can't any more. Enjoy the ending!
