Welcome to Pauper's Drop. Yes, he's very big and very nasty.
Once off the train, take a look around. Make sure to check to the right to find a healing station and (more importantly) a bot shutdown panel. Fail to hack the Healing Station, then shut the bots down and hack them. Once you're done with all your hacking and searching around the train, follow the arrow to the door. Hack the control panel to be let in.
Walk in, past the Gene Therapy station and into the next room. There are three splicers in this room that have no idea that you're here. Try to use this to your advantage as much as you can. Once dealt with, move on to the next room.
Walk around the Diner to the right, slowly, and be careful not to offend the big daddy. The back right corner of the Diner (outside) has a security camera. Hack it.
Ryan vs Lamb: Religious Rights by Sofia Lamb
In the far right back corner of the plaza is the Flower Emporium. go in through the door and on a cabinet is the diary.
Continue around the diner and up the stairs to the roof. Round the corner slowly because there's a turret up here. Hack the turret and cross the bridge over to the top of the Flower Emporium
Better Times with Lamb by Grace Halloway
behind the billboard on the floor, next to a crate, you'll find the diary.
Also on top of the Flower Emporium you'll find the Hacker's Delight Tonic, which heals you when you successfully hack something.
At this point I would recommend taking down the Rosie in the area and aquiring yourself a new little sister. Unlike the first Big Daddy, not all of them will always have a little sister. Make sure there's a little sister with the big daddy before you attack him. Even more so than the last Big Daddy I recommend making this fight close and personal because of the Rosie's preference to ranged combat. If you've managed to find the Adam for it, Winter Blast is very effective on Big Daddies. Once you work over the Big Daddy, grab yourself some Adam. The first corpse is in this area. Set up some trap rivets and drop your sister for some Adam. Just draw lines outward to the wall from the little hut next to the corpse.
Now that you have that done, feel free to grab something from the Gatherer's Garden if you like. Now head over to Sinclair's Deluxe Hotel. Go through the door, pick either path and then go through the door on the other side. Once you go down the hall a little bit you'll run into the Brute Splice who will block your path. Explore the area for some goods and, if need be, some bots. There's also a Drill Fuel station. Refill for free.
Wrong Side of the Tracks by Augustus Sinclair
In the office on the same side of the hall as the refuelling station, walk over to the desk on the left as you enter and the Diary is on top.
Head back towards the FishBowl Diner and head left towards the Gatherer's Garden. Continue down the hall a little ways and you'll see a healing station on your right. Then you'll see a Brute Splicer. Hurry and hack the Healing Station, then drill that Brute Splicer. Use Telekinesis to catch and throw things back at him or the other plasmids to stun him for easy pickings.
The End of the Line by Prentice Mill
Look directly at the healing station. Now do a 180. Walk all the way to the corner where there's a makeshift shrine. the Diary is on top of the shrine.
Clinic Code at the Fishbowl by Tobias Riefers
Walk over to the front door of Fontain Clincs. It's beside the door, leaning against the wall under the code entry panel.
Go over to Fontain Clinics and use the code 0047 to open the front door. Go up the stairs but be careful because a flaming drum will come down them. Kill the splicer. Just around the corner will be a security camera. If you time it right then you can run under it and hack it without using a dart. Go out the room to the left. Be Careful, dead ahead is a turret. Use a hacking dart and once that's hacked, run over to it. Just next to it on your right will be a hole in the roof of the pawn shop. Drop in and grab the research camera.
The Research Camera is simple. Select it as your weapon before you start a fight. Aim at an enemy (this includes Big Daddies and Big Sisters but not Little Sisters) and pull the trigger. After you pull the trigger, you will automatically switch back to your previous weapon and the camera will record your fight. During the fight try to use as many different types of attacks as you can to get more points. Go between plasmids and weapons. Use different plasmids and weapons and you'll finish your research quickly.
You want to research everything you can. After you do so much research on a type of splicer, you'll get a gift. Each Splicer type will give you four different gifts. You can see which in your information menu. Hit the back button and then scroll to the last menu on the right.
Now that you have the camera, you'll see a Splicer. Start recording on him and he'll break into the pawn shop. Kill him and you'll recieve your first bonus from your camera.
Go outside and back into Fontain Clinics. head up the stairs and straight out the door in front of you. Follow the makeshift platform around to the window to let you into the building. Take a right, use the Power to the People and then head up the stairs. Take the door on your right and grab the "Shorten Alarms" tonic on the filing cabinet.
Camera in Hock by Rock Flanagan, P.I.
In this room, it's sitting right on the desk.
Go back out into the hall way and continue down the hall and out through the hole in the wall. You'll see a group of splicers again. Remember to research!
Arrangements by Sofia Lamb
On the sheets just to the left of the Sisters vent.
Head to the right and just beyond the wall will be a security camera. Take out your research camera and get a clip of the security camera, then hack it. Continue into the building beyond and down the stairs. You will come out through a hole in the wall and be once again on top of the Pawn Shop. Don't drop down this time but proceed into the building ahead of you.
Crouch walk through the next door. Go around the mattress to the right and attack the splicer. Remember to Research! Head into the bathroom and then back out and a few more splicers will enter the room. Kill them.
Therapy with Grace I by Sofia Lamb
In this room with the mattress on the shelf against the wall (to the right as you enter the room).
You can leave this building and return to the Pawn Shop roof. Kill the splicer there and drop back into the Pawn shop and exit. The last thing to do is that there is an Adam corpse in this room. Have your sister find it, then set your traps and harvest the adam. There's no real trick here, you know how it goes. If you're brave enough to research then go ahead but I wouldn't bother unless a Brute Splicer shows up.
Once you've got your Adam, you can return the sister to the vent. Restock on anything you might need off of the vending machine in the area and then follow the arrow to Skid Row.
Things are a little tight in Skid Row so be careful not to accidently shoot the big daddy. Head forward a ways and you'll see a Security Camera for you to hack. To the right there is an emptied out store with a turret in it. Be careful because this turret fires rockets instead of bullets. Make sure you hack it. Just after the turret and camera, go to the end and take a left. Down the end is a Brute Splicer. Start Researching and go to town on him. Don't let up until you have your reward, the Drill Dash.
The Drill Dash is used by holding the RT and pressing (B). You will rush forward and slam whatever you hit. You should watch out for walls though because if you hit one then you'll be temporarily stunned. Great for doing damage to multiple foes at once or closing a gap and the damage is very high, allowing you to kill simple splicers in a single blow.
Mole by Stanley Poole
After finishing the Brute Splicer, head left and passed the security cam (feel free to hack it) and up the stairs, through the hole in the wall, around the corner and then in a niche in the right side wall. There will be a dead Rosie on the ground and the diary on the box.
Return to the main area of Skid Row and enter the shop you saw when you first entered, the Pharmacy. There's not much in here so go through the back into the lab and through that to the adjacent building, the Book store.
Blood and Lamb by Mark Meltzer
The diary is just sitting on the counter in the book store.
Hack the door panel to get out. take a sharp left and go down the alley immediately next to the Book store. follow this path up into an apartment.
Sunday Services by Jackie Rodkins
When you walk into the apartment upstairs with the Adam Corpse, it'll be on the floor right next to said corpse.
While you're here, you might as well harvest this body. Set up your traps and get ready. This room is pretty easy because there are only two ways in and both are through relatively tight spaces that you can litter with traps. Harvest and collect your Adam and then continue through apartment like you were before (leaving the room with the kitchen on your right). Go to the end of the hallway and take a left. In this next room on your left on the floor is a corpse with the Fire Storm tonic. Grab the tonic. Leave the apartment building through the hole in the wall and cross to the roof of the pharmacy.
Pauper's Drop by Andrew Ryan
On the roof around the corner is a hole in the wall (not the floor!) and inside this hole in the wall is the diary sitting on a box.
Drop into the Pharmacy and back out. Head down the alley to your right and over to the Limbo Room Entrance. Then proceed into the Limbo Room. Passed the health station into the first room you should see a plasmid waiting for you. Take it and walk into the next room just to the right of the counter. Kill the two splicers there.
Climb up on the stage and exit stage left and up the stairs. In the room at the top there's a Power to the People Station. Use it.
Closing the Limbo Room by Grace Halloway
Come out of the office room and take a right into the dressing room. The Diary is sitting on the table in front of the mirror.
Now there's only two more things to do in Skid Row. Hold (X) and follow to the last Adam corpse in Pauper's drop. Prepare yourself and harvest. Stay alive and you should be ok, there'll be a lot of bot help in the area (though if you don't OWN a couple of bots then you should try to hack some of the ones that come to help you.)
That was the easy part. Now for the last thing. Stock up on ammo and other supplies because it's time for Round Two with the Big Sister.
REMEMBER TO RESEARCH THE BIG SISTER!!!
This is the only enemy in the game where there's a limit to chances for research. Head over to the vent, take your camera out and wait. Once she appears, get the camera rolling and mix up how you attack her as much as possible without getting yourself killed. Remember where your hacked machines are and try to lead her to them so you can get some extra help. Remember Heavy Rivets and Armor-Piercing rounds on her. Drop the Little Sister in a vent.
Good Luck and happy researching!
Alright, now that you've offed the Big Sister, it's time for you to head back to Sinclair's Deluxe Hotel. Just follow the arrow and it should lead you to it.
Once you get back to the blocked area again, use your Drill Dash to destroy the rubble. Remember to refill your Drill at the station here and then head into the Hotel. Kill the few splicers, grab ammo from the vendor if you need it. Then head up the stairs on the right, take a right down the hall to the room there.
A Gift from Lamb by Grace Halloway
Continue through this room into the bathroom in the back. the diary is on the floor to the left of the cabinet but still leaning up against the cabinet.
Leave the room after you've searched it and head back toward the stairs, but not down them, and around the corner. You'll see a long hallway through the door there. Make your way back through the hotel, exploring rooms if you feel like it. Becareful whenever you backtrack though because Splicers may have spawned and set a trap for you. Go all the way to the end of the hall and make your way through the rooms to the right that are all jumbled together so you can get around the pile of rubble.
Once you're past the group of rooms, you'll come out into a hallway. On the left you'll see a vent shrine and the light of a security camera. Go to the right and stop at the corner. There's a turret around the corner. Do what you like to it. All you really need to do is get past the turret and through the door on the right side of the hall way for the Power to the People station that's there. Once you've gotten your upgrade, return back out the way you came and head towards the blue sheets and the vent shrine.
Hack the security camera and then turn your attention to the corpse on the table which is holding a tonic. Grab the tonic and some splicers will spawn. Dispose of them and continue down the hall (don't go up the ramp yet) and into the room. Go up the stairs back into the vent shrine room. Jump to the left across the giant hole in the floor
Profit Coming, Profit Going by Augustus Sinclair
On this platform the diary is sitting up against the crate on the floor.
After that, hop back down to the floor below and go up the ramp. Make your way down the hall exploring rooms as you go.
Where Has Harry Gone by Gloria Parson
In room 213 there's a smaller room with a turret and a safe. Stand next to the turret and turn toward the door leading to the hallway and you should see it on the bookshelf.
Eventually you won't be able to go further down this hall and you'll find Room 211 to your right and 212 on your left. Go into room 212.
The Butterfly by Gideon Wyborn
In room 212, off to the left is a butterfly room with a radion. On the same table as the radio you'll find the diary.
Leave room 212 out the right side and go up the fallen floor. Be careful going into the third floor hallway because there's a security camera at the end. Hack it and walk down the hallway.
What a Snap by Elliot Nelson
When you reach the security camera you just hacked, take a right and follow the walk way around to the end where you'll find a wheelchair and some crates. The diary is at the foot of the wheelchair.
Now go left from the security camera and around the walkway to Grace's apartment. Walk inside and on the left you'll see Eleanor's Room. Grab the Keen Observer Tonic.
Barbarism by Eleanor Lamb
Check under Eleanor's bed to find this diary.
Failing Lamb by Grace Halloway
Walk into the bedroom across from Eleanor's, the Diary is on the bed.
In Grace's bedroom, you'll see a poster of Sofia Lamb on the wall. Walk up to it and press (A) to rip it down. Hit the switch behind and it and walk through the closet on your left. Walk up to the glowing porthole window.
Now you'll be presented with a choice. If you let her live then she'll help you when she can later on and it'll contribute to the Savior Achievement. If you kill her then I guess you get the satisfaction of killing someone who hates you for being turned into a Big Daddy against your will.
Whatever you do, grab the key card on the desk and make tracks out of here. Follow the pathway around and the door on your right that was previously locked is now open. Feel free to go in, it'll give you a quick trip to the bottom. You'll have to fight your way out of Pauper's drop.
On the way out, just follow the arrow but take it slow. When you get to the Fishbowl diner you'll immediately face a rocket turret. Hack it, fast. Then head out. There's a Brute Splicer in the area of the Fishbowl diner. If you'd like you can research him but more importantly
Field Trial #1 by Leo Hartwig
This Diary is on the Brute Splicer near the Fishbowl Diner on your way out. Kill him and take it.
Leave the Fishbowl diner and follow the arrow to the station. Use the keycard in the booth at the station and then head over to the Train and hop on. Make sure you've got everything you want from Pauper's Drop before you throw the switch on the train.