| Name | App. | Treasure | Notes |
| Uroboros | 1-2 | Gold Ring | The Gold Ring can only be obtained if the player gets the kill, not using the furnace. |
| Popokarimu | 2-2 | - | |
| Ndesu | 2-3 | - | |
| Irving | 3-3 | - | |
| U-8 | 5-1 | - | |
| Uroboros Mkone | 5-2 | - | |
| Jill | 5-3 | - | |
| Wesker | 5-3 | Heart of Africa | Weske can not be defeated, but if dealt enough damage he will run from the Jill/Wesker fight and leave a VERY RARE Treasure behind. |
| Uroboros Aheri | 6-2 | - | It's spawn drops plenty of health and ammo for the player. Bring only the best weapons and get only ammo for them. |
| Wesker | 6-3 | - | |
| Wesker (Mutated) | 6-3 | - |
See the following pages for more information on each boss.
