| Enjoy Your Powers | Platinum | |
| Collect all trophies | ||
| Unstoppable | Silver | |
| Finish the game on Expert difficulty | ||
| Sacrifice | Bronze | |
| Risk your freedom to protect those you care about | ||
| Ruthless | Bronze | |
| Look out for yourself, no matter the consequences | ||
| Temperance | Bronze | |
| Practice self-control | ||
| Malice | Bronze | |
| Get them before they get you | ||
| Courage | Bronze | |
| Stand up for the helpless | ||
| Contempt | Bronze | |
| Don't fear the weak | ||
| Mercy | Bronze | |
| Everyone deserves a second chance | ||
| Revenge | Bronze | |
| An eye for an eye, a tooth for a tooth | ||
| Justice | Bronze | |
| Expose the corruption of the powerful | ||
| Dominance | Bronze | |
| Show the world that nobody can protect them | ||
| Reconciliation | Gold | |
| Finish the story with Good Karma | ||
| Rebellion | Gold | |
| Finish the story with Evil Karma | ||
| Everybody Out | Bronze | |
| Rescue 10 suspects from suspicion pens | ||
| Spin-off | Bronze | |
| Beat down 10 sign twirlers | ||
| Everyone's a Critic | Bronze | |
| Take out 10 street musicians | ||
| Just Say No | Bronze | |
| Bust 10 drug dealers | ||
| Freedom of Speech | Bronze | |
| Disrupt 10 activist rallies | ||
| What Did You Call Me? | Bronze | |
| Kill 10 obnoxious Akuran gang members | ||
| Someone Your Own Size | Bronze | |
| Rescue 10 escaped conduits from angry mobs | ||
| Walk It Off | Bronze | |
| Heal 10 wounded civilians | ||
| Kicking and Screaming | Bronze | |
| Finish off 10 wounded enemies or civilians | ||
| True Hero | Silver | |
| Achieve Level 5 Good Karma | ||
| Infamous | Silver | |
| Achieve Level 5 Evil Karma | ||
| Bweep! Bweep! Bweep! | Bronze | |
| Collect half the Blast Shards | ||
| Shardcore | Silver | |
| Collect all the Blast Shards | ||
| Nothing To See Here | Bronze | |
| Destroy half the D.U.P. security cameras | ||
| Blinded | Silver | |
| Destroy all of the D.U.P. security cameras | ||
| Inside Track | Silver | |
| Collect all the Informant Audio Logs | ||
| Blown Cover | Silver | |
| Defeat all the D.U.P. Secret Agents | ||
| Big Brother | Silver | |
| Destroy all the D.U.P. Hidden Cameras | ||
| Coloring Inside the Lines | Silver | |
| Complete all the Stencil Art | ||
| Prank Call | Bronze | |
| Complete a District Showdown | ||
| Hello Operator | Bronze | |
| Complete Showdowns in half of the districts | ||
| Final Showdown | Silver | |
| Complete all of the District Showdowns in the city | ||
| One Down | Bronze | |
| Clear the D.U.P. completely out of a district | ||
| Home Field Advantage | Bronze | |
| Clear the D.U.P. out of half the districts in the city | ||
| Clean Sweep | Silver | |
| Clear the D.U.P. out of the entire city | ||
| Total CARnage | Bronze | |
| Destroy 5 cars in 5 seconds | ||
| Drop Everything | Bronze | |
| Comet Drop over 170 meters | ||
| Keep It Up | Bronze | |
| Stay in the air for more than 45 seconds | ||
| Put That Anywhere | Bronze | |
| Defeat 10 enemies by detonating ammo crates | ||
| Hat Trick | Bronze | |
| Defeat an enemy using three different power sources | ||
| Double Smoke Stack Attack | Bronze | |
| Dash through two red air vents without touching the ground and then Comet Drop on an enemy | ||
| Cough Drop | Bronze | |
| Comet Drop on three coughing enemies | ||
| Make Fetch Proud | Bronze | |
| Hit three weak points with Neon Beam in 6 seconds | ||
| Excessive Force | Bronze | |
| Use a Karmic Streak attack to defeat exactly one enemy |
inFAMOUS: Second Son - Trophies
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