Your brother went over the two running away, so go ahead and investigate the truck that landed on its side. Go to the back and use the touchpad to lift the door off the guy, then watch the cutscene that occurs. When you stand up, try to walk forward only to dash forward with some strange powers. Keep doing this until you get to a tree, which you can dash through using the Circle button now.
Keep going through the trees until you come to your brother, who gets trapped underneath a car. Approach it and press and hold both thumbs on the touchpad to launch the car. Follow Reggie to a locked gate, which you must dash through. There doesn't seem to be a way into the cannery, but Delsin can use the vent by the door to get onto the roof and into the building.
Once you land, approach the blocked doorway straight ahead and Delsin will end up picking up the chain. Use Square to destroy the barriers and keep going until you meet up with Betty. After the cutscene, follow the Conduit and keep up with him, hitting him with your chain repeatedly. He will keep running away, so follow him as best as you can until you come outside.
There will be a cutscene here and your first Karma Choice. Hold L2 until you can press X to choose Good, or hold R2 for Evil. It's best to stick with one side throughout the game. Watch the cutscene to the end of the mission.
