There are two major forms of killing enemies in this game: Melee Combat and Weapons.
Melee
Melee attacks play a much larger role in Resident Evil 6. Unlike Resident Evil 5, which requiring a stunned enemy to do a melee attack, melee attacks can be used at any time to stun or kill an enemy. It will also offer the ability to take the weapon of an enemy and use it on the target for unique kills.
Weapons
See each Campaign section below for information on the items that appear in their campaign.
Infinite Ammo
After completing all four campaigns, the player can unlock infinite ammo for each weapon type through the Skills Menu. Take note that the skill needs to be equipped in one of the three skill slots in order to be used.
| Weapon Type | Cost |
| Handgun | 79,000 |
| Shotgun | 89,000 |
| Magnum | 99,000 |
| Sniper Rifle | 79,000 |
| Machine Pistol | 89,000 |
| Assault Rifle | 89,000 |
| Grenade Launcher | 99,000 |
| Crossbow | 79,000 |
