Before you can play any of the campaign modes, you will first need to finish the Prelude, which is basically a Tutorial chapter.
After the unknown individuals are blown up and the one individual wakes, look around with the R stick. You will be prompted to tap X/A to pull the unconsious woman to safety where it is revealed that the unknown male is, in fact, Leon S. Kennedy and the woman is Helena Harper.
Continue along the path and when prompted to, hit X/A to check the door and grab the pipe.
| The new indicator type, that you may not have encountered in other games, is a circle with highlighted areas around a button prompt. As the indicator reaches the highlighted area, hit the appropriate key to succed. You can skip a highlighted area with no negative effect to take your time when there are multiple highlighted areas. |
Break open the door, by using the prompts, and head through the next room to find a bunch of corpses and an area with a crashed jeep.
When you have control, head to the backseat door of the jeep to retreive a Green Herb and follow the instructions to heal Helena.
When the zombie arrives, you will learn more about QTE's (quick time events). The first two prompts will require you to rotate the L stick in a circular motion (direction does not matter and sometimes using your palm is faster than your finger), while the final one is simply hitting R1/RT.
| QTE's are often prompted in relation to enemies attacks or event actions. Sometimes failing a QTE will result in death, while others will simply cause damage to you. |
As you continue you will notice that most doors require you to press X/A to open them, but others require O/B. The O/B ones usually indicate story progression that both partners (in multiplayer) need to agree on and should usually only be approached once you have cleared an entire area.
As you reach the bridge, hop over the railing and make your way through the mass or zombies, you do not need to kill them all. Make a path until a cutscene and when you have control, do as the game indicates and hold down X/A as you use the L stick to Dash in any direction (in this case away from death and onto a helicopter).
Don't set down the controller since you are going to have some QTE's starting with rotating the L stick stick to kick off a zombie and ending with dodging a falling structure with X/A.
Head through the double doors and watch the ending and get The Longest Night acheivement/trophy.
