REWARDS - Respect, $9,000
Jizzy tells you to go meet T-Bone at the gas station in Easter Basin. Once there, a cutscene will occur in which T-Bone will give you a little test. Once that's over, drive to the van's location just up the street. Mike tells you to get on the bike nearby, but make sure you pick up the sniper rifle and rocket launcher before you do; you'll need them soon. You'll need to take out some roadblocks before the van gets to them.
Get on the bike and rush to the first roadblock. There are 2 officers and 2 cars for the first one. Destroy them with the rocket launcher, then make your way to the second roadblock. There are three vehicles and one guy on the ground, but also 2-3 guys in the building to the left. Blow the street guys up and use the sniper rifle to take out the guys in the building. You could also just autotarget the guys on the building to kill them without having to target them with your sniper rifle (any gun with auto will do).
The third and fourth roadblocks have snipers up high, as well as cops on the ground, so clear the ground ones first and then use your Sniper Rifle to clear the snipers. After all the roadblocks are gone, make sure the van gets to where it's going. CJ tells the guy to hide the van, since the cops will be here soon.
The mission is complete, but you now have a three star wanted level, so save your game at one of CJ's safehouses or get to a Pay-n-Spray to remove them.