Karma is the basic combo for Osiris. Relatively speaking, the combo doesn't do an exceptional amount of damage to an enemy but the combo is designed specifically for large groups of enemies that surround Dante. When used in this type of situation, this weapon easily does more damage than any other, especially since it will also quickly charge up the weapon's Feed feature.
This combo is the standby for Osiris. In most cases when you are on the ground, you will start with this combo when fighting a large group of enemies. Usually after performing this combo once in a large group, you'll create a large enough gap or kill enough enemies that it's beneficial to go with the Cleaver* attack for the next combo. The first two attacks will still be sweeping attacks, clearing any remaining enemies while the latter half of the combo is far more pointed for extra damage to a specific enemy. This kind of combo is perfect when faced with a large group of enemies where one of the enemies requires you to use angelic weapons such as a Frost Knight or Ghost Rage.
*While most distinct combos are their own attack, Cleaver is actually an upgrade to this attack.
