Sanctuary is a town for people hiding from Handsome Jack, and is run by the Crimson Raiders, a rebel faction that plans to bring Jack down from power. Players first enter Sanctuary as part of "The Road to Sanctuary" mission in the story.
It remains a central hub for players, as they can take on plenty of optional missions, play slot machines, talk to a plethora of NPCs and even buy/sell weapons and equipment.
- Crimson Raiders HQ
- Plan B
- Hunting the Firehawk
- Do No Harm
- Medical Mystery
- Claptrap's Secret Stash
- Rock, Paper, Genocide: Fire Weapons!
- Rock, Paper, Genocide: Shock Weapons!
- Rock, Paper, Genocide: Corrosive Weapons!
- Rock, Paper, Genocide: Slag Weapons!
- The Name Game
- Assassinate the Assassins
- Cult Following: Eternal Flame
- In Memoriam
- A Dam Fine Rescue